Ethylbisiminomethylguaiacol Manganese Chloride: The Ultimate Skin Protector

In the world of advanced skincare, few ingredients have garnered as much attention as EUK 134 Powder, INCI Name: ethylbisiminomethylguaiacol manganese chloride. This powerful antioxidant complex is transforming the landscape of skincare, offering unparalleled protection against environmental stressors. In this article, we delve into EUK 134 benefits and applications, and answer the crucial question: What Does EUK 134 Do to Skin?

What is EUK 134

EUK 134 is a synthetic molecule that mimics the natural enzyme superoxide dismutase. EUK 134 INCI name is ethylbisiminomethylguaiacol manganese chloride. It is mimic that is a synthetic superoxide dismutase (Superoxide dismutase, SOD) and catalase (CAT). It has high antioxidant activity. It is a new type of water-soluble synthetic small molecule o-phenylaldehyde ethylenediamine-manganese complex. It is one of the common ingredients in anti-aging skin care products.

EUK 134 Physical and Chemical Properties

EUK 134 Efficacy Mechanism

EUK-134 is a highly purified ingredient that mimics the activity of superoxide dismutase (SOD) and catalase in the body.

Antioxidants such as SOD scavenge superoxide anion free radicals and other oxidative molecular precursors, but in the process produce hydrogen peroxide (which can damage cells). EUK-134 has super antioxidant activity and its antioxidant effect is stronger. And it also has the function of catalase.

That is, in addition to decomposing oxygen free radicals into hydrogen peroxide, it can also further decompose hydrogen peroxide into water and oxygen. In addition, EUK-134 can inhibit β-amyloid (β-amyloid) and related protein-like fibril formation, and can protect human fibroblasts from cytotoxicity caused by glucose and glucose oxidase.

What Does EUK 134 Do to Skin

EUK 134 ethylbisiminomethylguaiacol manganese chloride has very strong antioxidant effect. Estee Lauder's brands are relatively mature in application. EUK-134 is added to many products to synergize antioxidants. Related papers have also been published to study the characteristics of EUK-134.

(Figure 1: Effect of UVA on catalase (CAT) activity (3.7μg/ml for EUK-134)

As shown in Figure 1: when UVA irradiation reaches 2 J/cm², the activity of catalase (CAT) in the solution drops to 60%, and when it reaches 6 J/cm², the activity of catalase drops to less than 40%. ; However, the EUK-134 group is still very strong at 12 J/cm², indicating that EUK-134 is more stable than CAT.

(Figure 2: Effect of UVB on EUK-134 activity)

As shown in pictres 2: the researchers first studied whether EUK-134 could maintain its catalase and SOD-like activities under UVB (300 mJ/cm²) irradiation. From the picture, the SOD-like and SOD-like activities of EUK-134 Catalase-like activity proven stable at UVB doses.

The above shows that EUK-134 is relatively stable, so what is its antioxidant effect?

To further demonstrate the antioxidant capacity of EUK-134, the researchers exposed cells to increasing concentrations of hydrogen peroxide (0.01-0.2 mM) for 10 minutes; 6 hours after H₂O₂ treatment, the concentration of p53 protein increased as the H₂O₂ concentration increased.

(Figure 3: EUK-134 pretreatment can reduce p53 N-terminal phosphorylation and p53 accumulation after UVB irradiation ("-" in the figure represents no EUK-134, "+" represents EUK-134 pretreatment)

Pretreatment with 50 μM EUK-134 for 24 hours almost inhibited this oxidative stress-induced p53 accumulation (Fig. 3a).

As shown in Figure 3b, when the concentration of EUK-134 increased (0.5-50 μM), the accumulation of p53 caused by UVB irradiation decreased;

As shown in Figure 3c, cells pretreated with EUK-134 (50 μM, 24 hours) can inhibit the accumulation of p53 protein at different UVB doses;

As shown in Figure 3d, in cells treated with EUK-134, The reduced accumulation of p53 protein after UVB damage is also closely related to the reduced phosphorylation of serine 15 phosphorylation site.

 (Figure 4: Effect of EUK-134 on lipid peroxides)

As shown in Figure 4, under UVA irradiation, lipid peroxide LPO on the skin surface significantly increases, while 0.1% EUK-134 can reduce lipid peroxides by approximately 95% and has catalase (CAT) activity.

(Figure5: Effects of 0.05% EUK-134 and 0.05% α-tocopherol on LPO under UVA irradiation)

As shown in Figure 5, when using antioxidants after UVA irradiation, 0.05% EUK-134 can still significantly reduce the level of lipid peroxidation on the skin surface, while α-tocopherol is less effective.

(Figure 6 Effect of EUK-134 on SqOOH)

As shown in Figure 6, SqOOH is squalene oxide, which is the main lipid peroxidation product on the skin surface induced by UVA. EUK-134 at 0.1% mM can significantly reduce (by 90%) the level of SqOOH exposed to UVA.

EUK-134 is a synthetic antioxidant ingredient. EUK-134 INCI name ethylbisiminomethylguaiacol manganese chloride It has a molecular weight of 416.74 and is a small molecule compound. EUK-134 has dual activity and is similar to superoxide. The functions of dismutase SOD and catalase CAT can resist oxidation, brighten skin tone, resist photodamage, prevent skin aging, and relieve skin inflammation.

EUK 134 Benefits for Skin

Neutralizes Free Radicals: EUK 134 is renowned for its ability to scavenge free radicals, the unstable molecules that accelerate aging and skin damage. By neutralizing these free radicals, EUK 134 helps prevent the formation of fine lines, wrinkles, and other signs of aging.

Reduces Oxidative Stress: The dual enzyme action of EUK 134 significantly reduces oxidative stress in the skin. This is crucial in protecting skin cells from damage caused by environmental factors such as UV radiation and pollution.

Enhances Skin Resilience: Regular use of skincare products containing EUK 134 can enhance the skin's resilience, making it more resistant to environmental aggressors. This leads to healthier, more radiant skin over time.

Supports Skin Healing: EUK 134's antioxidant properties support the skin's natural healing processes, making it an excellent choice for sensitive or compromised skin.

Prevents Cellular Damage: By acting as a protective barrier against cellular damage, EUK 134 helps maintain the integrity of skin cells, supporting overall skin health.

How to Choose the Right EUK 134 Manufacturer

Selecting a reputable manufacturer is crucial to ensure the cosmetics products formula quality and consistency of EUK 134. EUK 134' structure is difficult to test by HPLC, nuclear magnetism,

because EUK-134 contains manganese. This metal ion affects the nuclear magnetic resonance instrument and cannot obtain nuclear magnetic signals. So how to test it?

We use single crystal diffraction to test.  We grow a crystal that can be used for single crystal measurement. EUK-134 single crystal diffraction pattern(Contains 1 molecule of crystal water).

From the test data, XI AN CHEN LANG BIO TECH supply ethylbisiminomethylguaiacol manganese chloride EUK 134 99.55%; we specifically promise that the samples we provide to customers represent the quality of bulk products. If you need more EUK-134 COA, or other index, please send inquiry to Email: [email protected]