Does PQQ Increase Testosterone? Let's Explore the Potential Hormonal Benefits of Pyrroloquinoline Quinone
Our natural pyrroloquinoline quinone (PQQ) is a new type of prosthetic group. It is known as the "fourteenth vitamin" and the "King of Immunity" in the medical community.
It can stimulate the growth of human cells and improve the metabolism and growth function of biological tissues.
It is widely recognized for its antioxidant properties and its ability to support mitochondrial health, but does it have any effect on testosterone levels? Testosterone is a key hormone in the body, particularly for men, because it influences muscle mass, bone density, energy levels, and overall vitality. In this blog, we'll explore why it increase testosterone levels, and othr benefits of PQQ.
In recent years, almost 15 percent of couples worldwide trying to conceive have been affected by infertility, In recent years, with the in-depth study of male infertility, it has been found that oxidative stress causes changes in sperm structure and function, which is an important factor affecting the quality of male sperm. Oxidative stress increases the amount of oxygen free radicals (ROS) in our bodies, causing an imbalance in the body's antioxidant system. Excessive free radicals break down the sperm cell membrane, causing damage to the genetic material DNA, At the same time, it affects the energy generation and transportation of mitochondria, leading to the decrease of sperm cell vitality and accelerated apoptosis, which leads to the problem of male sperm quality.
The Role of Testosterone in the Body
Testosterone is a hormone produced mainly in the testes in men and in smaller amounts in the ovaries in women. It plays a critical role in regulating libido, muscle mass, bone density, red blood cell production, and overall well-being. As men age, testosterone levels tend to decline, leading to symptoms such as reduced energy, lower libido, and decreased muscle strength. Therefore, many people are interested in finding ways to boost testosterone levels, particularly through diet and supplementation.
How PQQ Improves Sperm Quality
Via previous articles, we know that PQQ has been extensively studied for its benefits on brain health and mitochondrial function, there is currently no direct evidence to suggest that PQQ increases testosterone levels. However, there are a few indirect ways in which PQQ might support hormonal balance, including testosterone:
Mitochondrial Catalyst
pyrroloquinoline quinone (PQQ) can pmprove mitochondrial function. Mitochondria play a key role in energy production, which is crucial for many bodily functions, including hormone production. PQQ can promote mitochondrial production and protect mitochondria from oxidative stress damage. It promotes intracellular mitochondrial synthesis by activating cAMP response element binding protein (CREB) and PGC-1α, Increase the activities of citrate synthase (CS) and cytochrome C oxidase (CCO) in mitochondria, and reduce sperm cell damage and sperm cell apoptosis caused by mitochondrial dysfunction. By enhancing mitochondrial health, PQQ ensures that the cells responsible for testosterone production in the testes.
Super Antioxidant Ability
PQQ can activate endogenous antioxidant mechanisms, allowing cells to respond to the threat of ROS more quickly and sensitively.
PQQ can catalyze the mutual conversion of oxygen and free radicals, thereby helping the body to maintain free radical balance;
PQQ can accelerate the reaction of "NAD+→NADH", and convert the utilized oxidized glutathione (GSSG) into reduced glutathione (GSH) more quickly, Maintain the rapid response of the antioxidant system in the human body to eliminate oxygen free radicals and protect sperm cells;
As a non-covalent binding prosthetic group, PQQ can synergistically combine with superoxide dismutase (SOD) to consume oxygen free radicals, thereby inhibiting the damage of superoxide anion free radicals to sperm cells.
PQQ has the ability to activate cellular oxidative stress protection mechanisms, thereby activating intracellular antioxidant pathways. PQQ can reduce the damage caused by oxidative stress to sperm cells by improving their antioxidant capacity.
PQQ Can Reverse Reproduction and Enhance Sexual Desire
After PQQ supplementation, the number of copulations rose to 12, and eight of those resulted in pregnancies in females. The mating rate increased from 6.7%~20%, and the pregnancy rate returned directly to 67%.
The results showed that male mice with reproductive senescence supplemented with PQQ could enhance sexual desire and increase mating rate; It can also enhance fertility and increase pregnancy rates.
PQQ Can Reverse Reproductive Aging and Enhance Sperm Quality
In addition, the researchers also evaluated the sperm quality of mice supplemented with PQQ.
They found that sperm count in mice increased significantly after PQQ supplementation.
After supplementing with PQQ, the sperm survival rate of mice basically returned to its original state.
Looking at other indicators of sperm, serum testosterone levels, testosterone/LH ratio and positive cells increased.
Moreover, the expression levels of proteins related to apoptosis and the expression levels of inflammation-related indicators were significantly reduced.
The results of this study show that PQQ supplementation can enhance the antioxidant capacity of testicular cells, reverse reproductive aging to a large extent, and significantly improve fertility.
Can PQQ Be Combined with Other Testosterone-Boosting Supplements
If you're looking to boost testosterone levels, PQQ may not be the primary supplement to rely on. However, it can be used alongside other proven testosterone-boosting supplements, such as:
Zinc: An essential mineral that plays a direct role in testosterone production.
Vitamin D: Low levels of vitamin D have been linked to lower testosterone levels, and supplementing with vitamin D has been shown to increase testosterone.
D-Aspartic Acid: An amino acid that has been shown to stimulate the release of hormones involved in testosterone production.
Fenugreek: A herb that has been studied for its potential to boost testosterone and improve libido.
Conclusion
Does PQQ increase testosterone? More experiments have shown that pyrroloquinoline quinone PQQ supplementation can enhance the antioxidant capacity of testicular cells, reverse reproductive aging to a large extent, and significantly improve fertility. If you're interested in boosting testosterone levels, consider combining PQQ with other supplements that have been specifically studied for their effects on testosterone, such as zinc, vitamin D, and D-aspartic acid. XI AN CHEN LANG BIO TECH is PQQ manufacturer and supplier, if you need more information about that, please contact us email: [email protected]