Does Urolithin A Reverse Aging

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Animal Experiments Show That: Urolithin A Can Reverse The Aging Of The Immune System

A team led by Nicola Vannini, head of the Oncology Department at the University of Lausanne's School of Medicine in Switzerland, conducted an experiment on mice using a natural compound called Urolithin A. This compound targets the mitochondria, the energy source of cells. The results showed that this intervention not only restored the blood regeneration capacity of hematopoietic stem cells in aged mice but also improved the immune system function of the aged mice. The related paper was published in the latest issue of the journal “Nature Aging".

The aging process is usually accompanied by a decline in the normal function of the hematopoietic and immune systems, making elderly individuals more susceptible to infections, blood disorders, and even the development of tumors. In the latest study, Vannini's team focused on the key players in the blood system: hematopoietic stem cells. These cells are responsible for generating various types of blood cells and play a crucial role in maintaining a healthy immune system. As age increases, the ability of hematopoietic stem cells to regenerate blood decreases, leading to impaired immune system function.

The latest study found that when Urolithin A was added as a dietary supplement, it not only revitalized the lymphoid area of the immune system in mice but also enhanced the overall performance of hematopoietic stem cells, demonstrating Urolithin A's potential to combat age-related immune system decline.

The research team explained that mitochondrial dysfunction has been identified as a contributing factor to the aging of hematopoietic stem cells. As a mitochondrial regulator, Urolithin A effectively restored mitochondrial function within these cells. Urolithin A is not present in food; it is produced by gut microbiota and is a natural metabolite found in ellagitannins. Foods such as pomegranates, nuts, and some berries contain ellagitannins.

Scientists point out that the latest research holds promise for developing interventions targeting age-related health conditions in the elderly and lays the foundation for clinical trials.

What Foods Are High In Urolithin A

Urolithin A itself does not exist directly in food, but is produced by intestinal microorganisms through the metabolism of ellagic acid and tannic acid. The following foods are rich in ellagic acid and tannic acid, which can be metabolized by intestinal flora to produce urolithin A.

Foods Rich in Ellagic Acid and Tannic Acid


Pomegranate is a rich source of ellagic acid and tannic acid. Pomegranate juice and pomegranate seeds contain high concentrations of ellagic acid.


Berry fruits such as raspberries, strawberries, blackberries and blueberries are rich in ellagic acid.


Nuts such as walnuts and pecans contain large amounts of tannic acid.

Dried fruits

Especially dried hawthorn and dried grapes, which contain a certain amount of ellagic acid and tannic acid.


Especially green tea and black tea, they contain a certain amount of tannic acid.

Red grapes

Red grapes and their products, such as red wine, also contain ellagic acid.

Urolithin A is produced by gut microbes metabolizing foods rich in ellagic acid and tannic acid.

By eating foods such as pomegranates, berries, walnuts, tea, and red grapes, you can increase the intake of ellagic acid and tannic acid in the body, thereby promoting the production of urolithin A. However, individual differences in gut microbiota can affect the efficiency of urolithin A production, so diets rich in these compounds may have different effects in different individuals.

What Are The Side Effects Of Urolithin A

Urolithin A has received a lot of attention for its many health benefits, but it is equally important to understand its potential side effects and safety. Although current research has focused on its beneficial effects, research on its side effects is relatively limited.

Urolithin A Safety and Toxicity Studies

Animal Experiments

In multiple animal experiments, urolithin A showed high safety. No obvious toxicity or serious side effects were observed even at higher doses. These studies indicate that urolithin A is safe within a certain range.

Human Trials

Preliminary clinical trials have shown that urolithin A is safe for humans within the recommended dose range.

Potential Side Effects Of Urolithin A

Gastrointestinal Issues

Some individuals may experience mild gastrointestinal discomfort, including bloating, diarrhea, or constipation. These symptoms are common with many dietary supplements and may be due to individual sensitivities.

Allergic Reactions

Though rare, allergic reactions can occur. Symptoms might include skin rashes, itching, or more severe reactions such as difficulty breathing. If an allergic reaction is suspected, discontinue use and seek medical attention immediately.

Impact on Liver and Kidney Function

High doses or long-term use of urolithin A could potentially affect liver and kidney function. While current studies have not shown significant adverse effects, those with pre-existing liver or kidney conditions should consult a healthcare provider before using Urolithin A supplements.

Can You Take NMN And Urolithin A Together

NMN and Urolithin A supplement can be taken together and may have complementary health benefits. NMN supports cellular energy metabolism and anti-aging by increasing NAD+ levels, while Urolithin A protects cellular health by promoting mitochondrial autophagy and reducing inflammation. Combining these two supplements provides a more comprehensive way to support overall health and anti-aging effects.


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