Fisetin Powder: A Dietary Antioxidant for Health Promotion
How Should I Take Fisetin Powder
Incorporating fisetin powder into your diet can be achieved through various means:
Dietary Sources
Eating foods rich in fisetin, such as strawberries, apples, persimmons, lotus root, onion, grapes, kiwis, peaches, cucumbers.
Supplements
As we all know that is lower fisetin dosage in daily foods. For those seeking higher doses or convenience, fisetin supplements are available in various forms, including capsules and tablets.
Eating Fisetin-Rich Foods vs. Taking Fisetin Supplements
The amount of fisetin you get from food every day will vary depending on the type of food and the amount you consume. The following are some foods rich in fisetin and their approximate content.
|
Foods |
Fisetin Content |
|
strawberries |
5~10mg/100g |
|
apples |
1-3mg/100g |
|
onions |
2-4mg/100g |
|
cucumbers |
1mg/100g |
If you add this physical list to your daily diet, you can get 14-30 mg of fisetin a day. However, these figures are estimates and actual intake will vary depending on the freshness, variety and preparation of the food.
If you have specific health goals or require a higher dose of fisetin, you may want to consider a fisetin supplement.
Common dosage ranges for fisetin supplements are usually between 10~500mg. Specific dosage will vary based on the product's formulation, brand, and individual needs.
Fisetin Dosage & Frequency
In a clinical study of colon cancer patients, 100 mg/day was effective for reducing inflammation.
However, as a senolytic, scientists believe fisetin should be administered using a “hit and run” protocol. This means administering doses intermittently, with long breaks in between.
According to ClinicalTrials.gov, fisetin dosage in human trials hovers around 20mg per kilogram of bodyweight. For individuals who weigh between 100 and 250 pounds, the dosage range looks like this:
100lbs (~45kg) = 900mg per day
150lbs (~68kg) = 1,360mg per day
200lbs (~91kg) = 1,820mg per day
Currently, no data is available on how long those breaks should be.
However, upcoming research at the Steadman Research Institute may offer insight. Researchers plan to evaluate the impact on fisetin on platelet rich plasma (PRP) during and after surgery. In the study, the following hit-and-run protocol is planned:
20mg/kg of bodyweight administered for two consecutive days prior to surgery, then for two consecutive days every 30 days afterward (e.g. on days 33, 34, 63, 64, 93, and 94)
Fisetin Absorption
When taken alone, fisetin is not easily absorbed. Combined with fat, however, fisetin may become more bioavailable. Coconut oil, olive oil, and fish oil are just a few examples of fats that can be paired with a fisetin supplement to improve absorption.
What is Fisetin Powder
Fisetin is a health-promoting dietary antioxidant. It belongs to the flavonoid class of compounds, often called flavonoids. Fisetin is found in many plants, especially citrus fruits and vegetables. It has strong antioxidant activity and can fight against the generation and damage of free radicals, thereby protecting the human body from oxidative stress. In addition, fisetin also has many health benefits such as anti-inflammatory, anti-cancer, lowering blood lipids, and anti-thrombosis.
It is well known that oxidative stress is a key factor in many diseases. Oxidative stress is caused by the excessive production and accumulation of free radicals, which can lead to lipid peroxidation of cell membranes, oxidative damage to DNA, and oxidative modification of proteins.
Oxidative stress has long been considered one of the main causes of human aging and many chronic diseases. However, proper intake of antioxidants can neutralize free radicals and reduce the degree of oxidative stress, thereby reducing the risk of disease.
Fisetin Powder Benefits and Risks
Fisetin Benefits for Human Body
Strong Antioxidant
Fisetin is a powerful antioxidant that helps neutralize free radicals in the body. Research shows that fisetin has stronger antioxidant activity than vitamin C and vitamin E.
It protects cells from oxidative stress damage by capturing and neutralizing free radicals. In addition, fisetin can also increase the activity of antioxidant enzymes in cells and promote the maintenance of redox balance.
Anti-Inflammatory
Fisetin has been shown to reduce inflammation by inhibiting inflammatory pathways and cytokines. This may benefit conditions characterized by chronic inflammation, such as arthritis.
Cognitive Health
Some studies suggest that fisetin may support brain health by reducing oxidative stress and inflammation, potentially enhancing cognitive function and memory. It may also protect against neurodegenerative diseases like Alzheimer's.
Anti-Cancer Potential
Studies have shown that fisetin powder can inhibit the proliferation and migration of tumor cells through multiple pathways. It can inhibit the proliferation of cancer cells by regulating the progression of the cell cycle. In addition, fisetin can inhibit tumor development by inducing apoptosis and inhibiting angiogenesis. These findings suggest that fisetin has potential as a new anticancer drug.
Metabolic Health
Fisetin might aid in managing blood sugar levels and improving insulin sensitivity, potentially benefiting individuals with diabetes or metabolic syndrome.
Skin Health
Due to its antioxidant and anti-inflammatory properties, fisetin may improve skin health by reducing signs of aging and protecting against skin damage.
Reduce Blood Lipids and Anti-thrombosis
Studies have shown that fisetin can inhibit the synthesis and absorption of cholesterol and reduce blood cholesterol levels. In addition, fisetin can inhibit platelet aggregation and thrombus formation, thereby reducing the risk of cardiovascular disease.
Fisetin Risks and Side Effects
Gastrointestinal Issues
Some individuals may experience mild gastrointestinal discomfort. It includes nausea or diarrhea, when taking fisetin supplements.
Allergic Reactions
Although rare, some people may have allergic reactions to fisetin or other components in the supplement. Symptoms may include rash, itching, or swelling.
Drug Interactions
It may interact with certain medications, such as blood thinners or medications metabolized by the liver. It’s important to consult with a healthcare provider before combining fisetin with other medications.
Lack of Long-Term Data
While fisetin has shown promising results in preclinical studies, there is limited long-term data on its safety and efficacy in humans. More research is needed to fully understand its long-term effects.
Dosage Concerns
High doses of fisetin powder might lead to unforeseen side effects or interactions. It’s crucial to follow recommended dosages and consult with a healthcare provider before starting any new supplement regimen.
Conclusion
As a health-promoting dietary antioxidant, fisetin powder has very strong antioxidant activity and multiple health benefits. It protects cells from damage caused by oxidative stress and reduces the risk of disease. In addition, fisetin also has various biological activities such as anti-inflammatory, anti-cancer, hypolipidemia, and anti-thrombosis. Therefore, we should consume appropriate amounts of fisetin through food to promote health and prevent the occurrence of chronic diseases. XI AN CHEN LANG BIO TECH is fisetin manufacturer and supplier, please send inquiry to Email: [email protected] if you want to buy fisetin.