The Latest Research Progress of NMN Powder and the Heart
Nicotinamide mononucleotide NMN supplier and manufacture. Cellular ferroptosis is a kind of iron-dependent cell death, involving mitochondria. It is caused by the accumulation of lipid peroxidation products in the cell, the inactivation of glutathione peroxidase 4 (GPX4), and the production of low levels of glutathione (GSH) from cysteine. Mitochondria are involved in the production of lipid peroxidation products, but the detailed mechanism is still unclear. Ferroptosis-related genes prostaglandin endoperoxide synthase 2 ( Ptgs2 ), acyl-CoA synthetase long-chain family member 4 ( Acsl4 ), and ChaC glutathione-specific γ-glutamyl cyclotransferase 1 have been reported (Chac1) expression is upregulated by ferroptosis. The lysosome function is crucial for intracellular iron metabolism, because free iron in the cytoplasm is toxic, and iron is thought to be stored in lysosomes.
Recently, a Japanese research team has studied whether mitochondrial dysfunction can induce ferroptosis in lysosomes. Researchers in the p32cKO model examined whether NMN treatment can improve lysosomal and autophagic function and prevent ferroptosis-induced heart failure.
In this study, researchers investigated whether long-term administration of NMN can restore heart function and prolong lifespan. Add NMN to the drinking water (1mg/ml) of mice, and feed WT and p32cKO mice NMN from 2 months to 9 months old to examine its effect on heart function. It was observed that the mRNA expression of atrial natriuretic factor (ANF) and β-myosin heavy chain (β-MHC) (markers of heart failure) increased in p32cKO mice, but NMN treatment partially improved this situation. (Figure 1A). p32cKO promotes myocardial fibrosis, and NMN administration can also reverse this condition (Figure 1B).
The research demonstrates that the administration of nicotinamide mononucleotide (NMN) can improve the cardiac dysfunction in p32cKO mice.
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References: Yagi M, Do Y, Hirai H, Miki K, Toshima T, Fukahori Y, Setoyama D, Abe C, Nabeshima YI, Kang D, Uchiumi T. Improving lysosomal ferroptosis with NMN administration protects against heart failure. Life Sci Alliance. 2023 Oct 4;6(12):e202302116. doi: 10.26508/lsa.202302116. PMID: 37793777; PMCID: PMC10551641.