Fisetin powder is a naturally occurring flavonoid found in fruits like strawberries, apples, and persimmons. it has gained attention for its potential health benefits, including anti-aging and anti-inflammatory. However, due to its low natural concentration in foods, many people turn to supplements to achieve desired health outcomes.
Let’s Learn Fisetin's Benefits
XI AN CHEN LANG BIO TECH is natural fisetin powder manufacturer and global supplier. It is extracted from cotinus extract. It is know for anti-aging and anti-inflammatory. Some health manufacture company think it has senolytic properties. Which means it can help clear out senescent cells that contribute to aging and disease. It also has anti-carcinogenic effects, as studies have shown its ability to suppress tumor growth in animal models. Furthermore, fisetin may extend lifespan and improve healthspan by reducing the risk of age-related diseases like Alzheimer's and certain cancers.
Fisetin Benefits
Fisetin can scavenge free radicals and enhance glutathione
Fisetin directly scavenges free radicals, enhances glutathione levels, and may help regulate the production of many proteins.
Fisetin also has anti-tumor effects
It has anti-human lung cancer cells, anti-uterine cancer cells, anti-human skin cancer cells and anti-human colon cancer cells.
Fisetin also has unique effects on brain health, cognition and memory.
Fisetin Bioavailability
Poor Solubility: Fisetin has low water solubility, which means it is not easily absorbed in the gastrointestinal tract. This limits its ability to reach systemic circulation and exert its effects.
Rapid Metabolism: Once absorbed, fisetin is rapidly metabolized in the liver, further reducing its concentration in the blood.
Low Stability: Fisetin can be unstable in the digestive system, leading to degradation before it can be absorbed.
Fisetin may be unstable in the digestive system, causing degradation before being absorbed.
How to Improve Fisetin Bioavailability
Many customers asked us how to take fisetin powder supplement? Here are some ways to improve fisetin bioavailability.
Nanoformulations
Nanoparticles: Encapsulating fisetin in nanoparticles can enhance its solubility and stability, improving absorption.
Liposomes: These are lipid-based vesicles that can encapsulate fisetin, enhancing its solubility and protecting it from degradation.
Solid Lipid Nanoparticles (SLNs)
SLNs can improve the solubility and stability of fisetin, enhancing its absorption and bioavailability.
Co-crystals
Co-crystallization with other compounds can improve the solubility and stability of fisetin, enhancing its bioavailability.
Use of Absorption Enhancers
Combining fisetin with compounds that enhance intestinal absorption, such as piperine, can improve its bioavailability.
Inclusion Complexes
Cyclodextrins are cyclic oligosaccharides that can form inclusion complexes with fisetin, enhancing its solubility and stability.
Micellar Formulations
Formulating fisetin in micelles, which are aggregates of surfactant molecules, can enhance its solubility and absorption.
Phospholipid Complexes
Complexing fisetin with phospholipids can enhance its lipophilicity, improving its absorption and bioavailability.
Dietary Fat
Consuming fisetin with dietary fats can enhance its solubility and absorption due to increased bile secretion.
Popular Fisetin Supplement Forms in Market
Capsules and Softgels
These are the most common forms of fisetin supplements. Capsules often contain additional ingredients to improve bioavailability, such as oils or piperine (black pepper extract). Softgels may offer better absorption due to their liquid content.
Powder
Fisetin powder allows for flexible dosing and can be mixed with food or beverages. However, like capsules, it may require a fat source to enhance absorption. Some users prefer powder for its customizable dosing options.
Liposome-Encapsulated Fisetin
This advanced form involves encasing fisetin molecules in liposomes, which are tiny fat-like spheres that improve the delivery and absorption of the compound. Liposomal supplements tend to be more expensive but are favored for their enhanced bioavailability.
Combination Supplements
Some products combine fisetin with other senolytic compounds like quercetin or curcumin. These combinations may offer synergistic benefits, enhancing the overall effectiveness of the supplement.
Fisetin Dosage
How to choose fisetin dosage in supplements, according to the effect you want to get. For general health support, fisetin is often taken in doses of 100~500 mg per day.
Cognitive and Anti-aging Benefits: Some studies have used doses up to 100 mg/kg in animal studies, but for humans, a conservative dose around 100 to 300 mg daily is often recommended for its neuroprotective and anti-aging effects.
Fisetin dosage in skincare: In cosmetics, fisetin is usually used in lower concentrations, typically between 0.01%~0.1%. This is because of the highly effective antioxidant properties of fisetin, which allows it to play a significant role in cosmetics even at low concentrations.
How to Choose the Right Fisetin Supplement
When select a fisetin supplement, consider the following factors
Purity and Quality: Choose products from reputable brands that adhere to Good Manufacturing Practices (GMP) and undergo third-party testing for quality and purity.
Formulation: Look for supplements that include bioavailability enhancers or are designed to be taken with a fat source to improve absorption.
Intended Use: Determine whether you prefer a daily supplement or a high-dose regimen for occasional use, such as the senolytic protocol.
Fisetin Safety and Side Effects
Fisetin powder is generally considered safe, with no significant side effects reported in clinical studies. However, due to limited long-term safety data, pregnant women and children should avoid fisetin supplements. Additionally, fisetin may interact with blood-thinning medications or those affecting blood sugar levels, so consulting a healthcare provider before starting supplementation is advisable.
Conclusion
The best form of fisetin to take depends on individual preferences, health goals, and absorption considerations. Whether you opt for capsules, powders, or advanced liposomal formulations, ensure the supplement is of high quality and suits your specific needs. At the same time, we must pay attention to a balanced diet so that we can have a healthy body and strong immunity. We are mainly supply wholesale and fisetin powder with best price, please contact us email: [email protected] if you want to buy fisetin.